International study of factors affecting human chromosome translocations

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منابع مشابه

Chromosome Translocations and Human Cancer1

quent findings that the great majority of human hematopoietic malignancies carry specific chromosomal alterations (3, 4) have suggested that such nonrandom chromosomal changes may be involved in the pathogenesis of human malignancies. This view, however, was not shared by many investigators outside the field of cancer cytogenetics, who regarded such chromosomal alter ations as epiphenomena of t...

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Screening and quantification of multiple chromosome translocations in human leukemia.

BACKGROUND Characterization of fusion gene transcripts in leukemia that result from chromosome translocations provides valuable information regarding appropriate treatment and prognosis. However, screening for multiple fusion gene transcripts is difficult with conventional PCR and state-of-the-art real-time PCR and high-density microarrays. METHODS We developed a multiplex reverse transcripti...

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ژورنال

عنوان ژورنال: Mutation Research/Genetic Toxicology and Environmental Mutagenesis

سال: 2008

ISSN: 1383-5718

DOI: 10.1016/j.mrgentox.2008.01.005